CovidV2, new, Analysis, bibRecord, 000818

Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors

Identifieur interne : 000818 ( new/Analysis ); précédent : 000817; suivant : 000819

Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors

Auteurs : D. Sulzer [États-Unis] ; E. Holtzman [États-Unis]

Source :

Journal of Neurocytology [ 0300-4864 ] ; 1989-08-01.

RBID : ISTEX:FFADA1657A22084CED7E2A5F6868950CD49E8D99

English descriptors

Teeft :
- Acidification, Ammonium, Ammonium chloride, Annual review, Biological chemistry, Ceil biology, Cell biology, Cell bodies, Cell surface, Cisterna, Cone cell, Cycling, Endocytic, Endocytosis, Endosomes, Experiments retinas, Frog, Heuser, Heuser reese, Holtzman, Holtzman mercurio, Horseradish peroxidase, Large vacuoles, Liscum, Lysosome, Membrane, Membrane cycling, Mercurio, Mercurio holtzman, Miller heuser, Nerve terminals, Neuron, Okhuma poole, Osmotic effects, Other cell types, Peroxidase, Photoreceptor, Photoreceptor terminals, Photoreceptors, Plasma membrane, Presynaptic, Presynaptic terminal, Presynaptic terminals, Raviola, Recovery experiments, Recycling, Retina, Room temperature, Schacher, Schaeffer raviola, Secretory, Such vacuoles, Sulzer, Synaptic, Synaptic vesicle membrane, Synaptic vesicles, Terminal, Tracer, Transmitter release, Typical synaptic vesicles, Unlabelled vacuoles, Vacuolation, Vacuole, Vesicle, Weak bases.

Abstract

Summary: By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas ofRana pipiens maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.

Url:

DOI: 10.1007/BF01474548

Affiliations:

Links to Exploration step

ISTEX:FFADA1657A22084CED7E2A5F6868950CD49E8D99

Le document en format XML

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<front><div type="abstract" xml:lang="en">Summary: By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas ofRana pipiens maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.</div>
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Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors

Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

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	Serveur d'exploration Covid (26 mars)
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